Identifying Compound-Target Associations by Combining Bioactivity Profile Similarity Search and Public Databases Mining

@inproceedings{Cheng2011IdentifyingCA,
  title={Identifying Compound-Target Associations by Combining Bioactivity Profile Similarity Search and Public Databases Mining},
  author={Tiejun Cheng and Qingliang Li and Yanli Wang and Stephen H. Bryant},
  booktitle={Journal of Chemical Information and Modeling},
  year={2011}
}
Molecular target identification is of central importance to drug discovery. Here, we developed a computational approach, named bioactivity profile similarity search (BASS), for associating targets to small molecules by using the known target annotations of related compounds from public databases. To evaluate BASS, a bioactivity profile database was… CONTINUE READING