Identifying Complexes from Protein Interaction Networks According to Different Types of Neighborhood Density

@article{Fan2012IdentifyingCF,
  title={Identifying Complexes from Protein Interaction Networks According to Different Types of Neighborhood Density},
  author={Jia-Hao Fan and Jianer Chen and Sing-Hoi Sze},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  year={2012},
  volume={19 12},
  pages={1284-94}
}
To facilitate the realization of biological functions, proteins are often organized into complexes. While computational techniques are used to predict these complexes, detailed understanding of their organization remains inadequate. Apart from complexes that reside in very dense regions of a protein interaction network in which most algorithms are able to identify, we observe that many other complexes, while not residing in very dense regions, reside in regions with low neighborhood density. We… CONTINUE READING
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