Identify the key amino acid of BAFF binding with TACI.

  title={Identify the key amino acid of BAFF binding with TACI.},
  author={Renxi Wang and Ru Wang and Ning Ma and Yueling Guo and H A Xiao and Guojiang Chen and Gencheng Han and Chunmei Hou and Beifen Shen and Jiannan Feng and Yan Li},
  journal={Cellular immunology},
  volume={284 1-2},
B-cell activating factor (BAFF) has been used as a therapeutic target. To develop BAFF-specific small molecular inhibitors, it is necessary to know the key amino acid in the BAFF binding with its receptor. The key binding amino acid of BAFF interacting with its receptor TACI (trans-membrane activator and calcium modulator and cyclophilin ligand interactor) was analyzed based on the computer-guided molecular modeling method. According to theoretical prediction, a series of key amino acid mutants… CONTINUE READING