Identification of viral mutants by mass spectrometry.

@article{Lewis1998IdentificationOV,
  title={Identification of viral mutants by mass spectrometry.},
  author={Jeffery K Lewis and Mohammed Bendahmane and Thomas James Smith and Roger N. Beachy and Gary Siuzdak},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 15},
  pages={8596-601}
}
A method to identify mutations of virus proteins by using protein mass mapping is described. Comparative mass mapping was applied to a structural protein of the human rhinovirus Cys1199 --> Tyr mutant and to genetically engineered mutants of tobacco mosaic virus. The information generated from this approach can rapidly identify the peptide or protein… CONTINUE READING