Identification of viral genomic elements responsible for rabies virus neuroinvasiveness.

  title={Identification of viral genomic elements responsible for rabies virus neuroinvasiveness.},
  author={Milosz Faber and Rojjanaporn Pulmanausahakul and Kazuhiko Nagao and Mikhail Prosniak and Amy B Rice and Hilary Koprowski and Matthias J Schnell and Bernhard Dietzschold},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 46},
Attenuated tissue culture-adapted and natural street rabies virus (RV) strains differ greatly in their neuroinvasiveness. To identify the elements responsible for the ability of an RV to enter the CNS from a peripheral site and to cause lethal neurological disease, we constructed a full-length cDNA clone of silver-haired bat-associated RV (SHBRV) strain 18 and exchanged the genes encoding RV proteins and genomic sequences of this highly neuroinvasive RV strain with those of a highly attenuated… CONTINUE READING

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