Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines.

@article{Drexler2003IdentificationOV,
  title={Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines.},
  author={Ingo Drexler and Caroline Staib and Wolfgang Kastenmuller and Stefan Stevanovi{\'c} and Bodil Kappel Schmidt and François A. Lemonnier and Hans-Georg Rammensee and Dirk H Busch and H. Christian Bernhard and Volker Erfle and Gerd Sutter},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 1},
  pages={
          217-22
        }
}
Despite worldwide eradication of naturally occurring variola virus, smallpox remains a potential threat to both civilian and military populations. New, safe smallpox vaccines are being developed, and there is an urgent need for methods to evaluate vaccine efficacy after immunization. Here we report the identification of an immunodominant HLA-A*0201-restricted epitope that is recognized by cytotoxic CD8(+) T cells and conserved among Orthopoxvirus species including variola virus. This finding… CONTINUE READING
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