Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor

@article{Lewis2001IdentificationOU,
  title={Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor},
  author={Kathy A. Lewis and C. Li and Marilyn H. Perrin and Amy L. Blount and Koichi S. Kunitake and Cynthia J. Donaldson and Joan M. Vaughan and Teresa M Reyes and J{\'o}zsef Guly{\'a}s and Wolfgang H. Fischer and Louise M. Bilezikjian and Jean E. Rivier and Paul E Sawchenko and Wylie W. Vale},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98},
  pages={7570 - 7575}
}
  • K. Lewis, C. Li, +11 authors W. Vale
  • Published 19 June 2001
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
The corticotropin-releasing factor (CRF) family of neuropeptides includes the mammalian peptides CRF, urocortin, and urocortin II, as well as piscine urotensin I and frog sauvagine. The mammalian peptides signal through two G protein-coupled receptor types to modulate endocrine, autonomic, and behavioral responses to stress, as well as a range of peripheral (cardiovascular, gastrointestinal, and immune) activities. The three previously known ligands are differentially distributed anatomically… 
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TLDR
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Teneurin C-terminal associated peptides (TCAP): modulators of corticotropin-releasing factor (CRF) physiology and behavior
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TLDR
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References

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Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors
  • T. Reyes, K. Lewis, +8 authors P. Sawchenko
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2001
TLDR
Cl cloning and initial characterization of a previously unidentified CRF-related neuropeptide, urocortin II (Ucn II), are described, which is expressed centrally and binds selectively toCRF-R2, and identified as a new member of the CRF family of neuropePTides.
Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor
TLDR
This work characterized another mammalian member of the CRF family and localized its urotensin-like immunoreactivity to, and cloned related complementary DNAs from, a discrete rat midbrain region, and deduced a peptide that is related to u Rotensin and CRF, which is named urocortin, which could be an endogenous ligand for type-2 CRF receptors.
Expression cloning of a human corticotropin-releasing-factor receptor.
TLDR
The cloning of a cDNA coding for a CRF receptor from a human corticotropic tumor library is reported, which encodes a 415-amino acid protein comprising seven putative membrane-spanning domains and is structurally related to the calcitonin/vasoactive intestinal peptide/growth hormone-releasing hormone subfamily of G protein-coupled receptors.
Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain.
TLDR
The isolation of a cDNA clone that encodes a second member of the corticotropin-releasing factor (CRF) receptor family, designated as the CRF2 receptor, demonstrates the presence of another functional CRF receptor, with significant differences in the pharmacological profile and tissue distribution from the CRFs.
Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain
TLDR
The pattern ofCRF receptor mRNA expression in the brain, pituitary gland, and other organs corresponds precisely to that predicted for the classic CRF receptor, suggesting that this receptor serves to mediate the known biological effects of CRF on behavior, stress, and homeostasis.
A role for corticotropin releasing factor and urocortin in behavioral responses to stressors
TLDR
Data suggest that CRF systems in the brain have a unique role in mediating behavioral responses to diverse stressors, and these systems may be particularly important in situations were an organism must mobilize not only the pituitary adrenal system, but also the central nervous system in response to environmental challenge.
Cloning and functional expression of a rat brain corticotropin releasing factor (CRF) receptor.
TLDR
The results suggest that the brain expresses a CRF receptor similar to that in the pituitary, and the structure of the cDNA for a rat brainCRF receptor (rCRF-R) which was cloned by hybridization from a ratbrain cDNA library is reported.
Ligand requirements of the human corticotropin-releasing factor-binding protein.
TLDR
Testing the affinity of recombinant CRF-BP for synthetic analogs of CRF and peptides in the CRF family indicates that residues 9-28 are crucial for ligand binding, and suggests specific pharmacological inhibitors of the ligand-binding protein interaction might be used to therapeutically elevate free CRF levels.
Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors
TLDR
Cloning a CRF receptor complementary DNA by expression in COS‐7 cells of a cDNA library from the AtT20 mouse pituitary tumour cell line suggests a major role for this neuropeptide in the integration of the overall physiological and behavioral responses of an organism to stress.
Urocortin Expression in Rat Brain: Evidence Against a Pervasive Relationship of Urocortin‐Containing Projections With Targets Bearing Type 2 CRF Receptors
TLDR
A central UCN system whose organization suggests a principal involvement in motor control and sensorimotor integration and its participation in stress‐related mechanisms would appear to derive principally by virtue of projections to the spinal intermediolateral column, the NTS, and the paraventricular nucleus is defined.
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