Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage

@article{Strappe2005IdentificationOU,
  title={Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage},
  author={Padraig M. Strappe and David W. Hampton and Douglas E Brown and Bego{\~n}a Cach{\'o}n-Gonz{\'a}lez and Maeve A Caldwell and James W. Fawcett and Andrew M. L. Lever},
  journal={Retrovirology},
  year={2005},
  volume={2},
  pages={55 - 55}
}
Lentiviral vectors have shown immense promise as vehicles for gene delivery to non-dividing cells particularly to cells of the central nervous system (CNS). Improvements in the biosafety of viral vectors are paramount as lentiviral vectors move into human clinical trials. This study investigates the packaging relationship between gene transfer (vector) and Gag-Pol expression constructs of HIV-1, HIV-2 and SIV. Cross-packaged vectors expressing GFP were assessed for RNA packaging, viral vector… CONTINUE READING