Identification of uncoupling protein 4 from the blood-sucking insect Rhodnius prolixus and its possible role on protection against oxidative stress.

@article{AlvesBezerra2014IdentificationOU,
  title={Identification of uncoupling protein 4 from the blood-sucking insect Rhodnius prolixus and its possible role on protection against oxidative stress.},
  author={Michele Alves-Bezerra and Daniela Cosentino-Gomes and Lisvane Paes Vieira and Nath{\'a}lia Rocco-Machado and Katia Calp Gondim and Jos{\'e} Roberto Meyer-Fernandes},
  journal={Insect biochemistry and molecular biology},
  year={2014},
  volume={50},
  pages={24-33}
}
Uncoupling proteins (UCPs) play a critical role in the control of the mitochondrial membrane potential (ΔΨm) due to their ability to dissipate the proton gradient, which results in the uncoupling of mitochondrial respiration from ATP production. Most reactive oxygen species generation in mitochondria occurs in complex III, due to an increase of semiquinone (Q(-)) half-life. When active, UCPs can account as a potential antioxidant system by decreasing ΔΨm and increasing mitochondrial respiration… CONTINUE READING

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