Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.

@article{Dijke1994IdentificationOT,
  title={Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.},
  author={Peter Ten Dijke and Hidetoshi Yamashita and T. Kuber Sampath and A. Hari Reddi and Miguel Est{\'e}vez and Donald L. Riddle and Hidenori Ichijo and C H Heldin and Kohei Miyazono},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 25},
  pages={16985-8}
}
Bone morphogenetic proteins (BMPs) are multifunctional proteins, structurally related to transforming growth factor-beta (TGF-beta) and activin. TGF-beta and activin exert their effects by forming heteromeric complexes of type I and type II serine/threonine kinase receptors. We have previously identified a series of type I serine/threonine kinase receptors, termed activin receptor-like kinase (ALK)-1 to -6. ALK-5 is a TGF-beta type I receptor, whereas ALK-2 and ALK-4 are activin type I… CONTINUE READING
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