Identification of two transcription activation units in the N-terminal domain of the human androgen receptor.

  title={Identification of two transcription activation units in the N-terminal domain of the human androgen receptor.},
  author={Guido Jenster and Hetty A. van der Korput and Jan Trapman and Albert O. Brinkmann},
  journal={The Journal of biological chemistry},
  volume={270 13},
To locate in detail the regions in the human androgen receptor (AR) involved in transcription activation, a series of N-terminal deletions was introduced in the wild type AR and in a constitutively active AR. The different constructs were tested for their capacity to activate transcription. Almost the entire N-terminal domain (residues 1-485) was necessary for full wild type AR activity when cotransfected with the (GRE)2tkCAT reporter in HeLa cells. In contrast, a smaller part of the N-terminal… CONTINUE READING
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