Identification of two teaghrelins in Shy-jih-chuen oolong tea.

@article{Li2019IdentificationOT,
  title={Identification of two teaghrelins in Shy-jih-chuen oolong tea.},
  author={Yue-Chiun Li and Chieh-Ju Wu and Yi-Chiao Lin and Ruo-Hsuan Wu and Wen-Ying Chen and Ping-Chung Kuo and Jason T.C. Tzen},
  journal={Journal of food biochemistry},
  year={2019},
  volume={43 4},
  pages={
          e12810
        }
}
Teaghrelins are unique acylated flavonoid tetraglycosides originally identified in Chin-shin oolong tea, and proposed to be potential oral analogs of ghrelin. Two acylated flavonoid tetraglycosides were isolated from Shy-jih-chuen oolong tea, and their chemical structures were determined to be quercetin and kaempferol 3-O-[α-L-arabinopyranosyl(1 → 3)][2"-O-(E)-p-coumaroyl] [β-D-glucopyranosyl(1 → 3)-α-L-rhamnopyranosyl(1 → 6)]-β-D-glucoside. These two compounds were extremely similar to the two… 
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Characterisation of teaghrelin-like principles from Assam tea cultivated in Thailand

Two new teaghrelin-like compounds were purified and characterised from Assam tea varieties collected in Thailand, and did not display notable anti-inflammatory activity in human neutrophils assay.

Quercetin 3-O-malonylglucoside in the leaves of mulberry (Morus alba) is a functional analog of ghrelin.

The relatively abundant compound, quercetin 3-O-malonylglucoside was subjected to a bioactivity assay, and the result confirmed that it was able to increase the growth hormone secretion of rat anterior pituitary cells and presumably a key ingredient for the anti-aging activity of mulberry leaves.

Anti-Inflammatory Principles from the Needles of Pinus taiwanensis Hayata and In Silico Studies of Their Potential Anti-Aging Effects

Results suggest the flavonoids are responsible for the potential anti-aging effects of pine needle tea.

Teaghrelin Protects SH-SY5Y Cells against MPP+-Induced Neurotoxicity through Activation of AMPK/SIRT1/PGC-1α and ERK1/2 Pathways

The neuroprotective potential of teaghrelin against PD was explored in a cell model in which human neuroblastoma SH-SY5Y cells were treated with the mitochondrial toxin 1-methyl-4-phenylpyridinium (MPP+).

Characterization of teaghrelin-like compounds from tea cultivars

Two new teaghrelin-like compounds were characterized from tea cultivars, and their chemical structures were established by the spectroscopic and spectrometric analysis, but due to the different location of rhamnose, these two teagh Relins may not show significant ghrelin receptor affinity.

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Teaghrelins, unique acylated flavonoid tetraglycosides in Chin-shin oolong tea, are putative oral agonists of the ghrelin receptor.

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