Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor.

@article{Strader1989IdentificationOT,
  title={Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor.},
  author={Catherine D. Strader and Mari Rios Candelore and W S Hill and Irving S. Sigal and Richard Alastair Dixon},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 23},
  pages={13572-8}
}
Pharmacophore mapping of the ligand binding domain of the beta-adrenergic receptor has revealed specific molecular interactions which are important for agonist and antagonist binding to the receptor. Previous site-directed mutagenesis experiments have demonstrated that the binding of amine agonists and antagonists to the receptor involves an interaction… CONTINUE READING