Identification of two related pentapeptides from the brain with potent opiate agonist activity

@article{Hughes1975IdentificationOT,
  title={Identification of two related pentapeptides from the brain with potent opiate agonist activity},
  author={J. Hughes and T. Smith and H. Kosterlitz and L. Fothergill and B. Morgan and H. Morris},
  journal={Nature},
  year={1975},
  volume={258},
  pages={577-579}
}
  • J. Hughes, T. Smith, +3 authors H. Morris
  • Published 1975
  • Chemistry, Medicine
  • Nature
  • Enkephalin, a natural ligand for opiate receptors is composed of the pentapeptides H–Tyr–Gly–Gly–Phe–Met–OH and H–Tyr–Gly–Gly–Phe–Leu–OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl–Edman procedure and by mass spectrometry followed by synthesis and comparison of the natural and synthetic peptides. 
    3,430 Citations
    Opiate receptor affinity of peptides related to Leu-enkephalin.
    • 66
    Potent tetrapeptide enkephalins.
    • 15
    Evidence for analgesic activity of enkephalin in the mouse
    • 233
    Morphine-like peptides in mammalian brain: isolation, structure elucidation, and interactions with the opiate receptor.
    • R. Simantov, S. Snyder
    • Chemistry, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1976
    • 194
    • PDF
    Analogues of both Leu- and Met-enkephalin containing a constrained dipeptide isostere prepared from a Baylis-Hillman adduct
    • 13

    References

    SHOWING 1-10 OF 16 REFERENCES
    Some thoughts on the significance of enkephalin, the endogenous ligand.
    • 261
    Search for an endogenous ligand for the opiate receptor.
    • 300
    An endogenous morphine-like factor in mammalian brain.
    • 377
    Purification and properties
    • 2,140
    • PDF