• DOI:10.1038/258577a0
Corpus ID: 95411

Identification of two related pentapeptides from the brain with potent opiate agonist activity

@article{Hughes1975IdentificationOT,
  title={Identification of two related pentapeptides from the brain with potent opiate agonist activity},
  author={J. Hughes and T. Smith and H. Kosterlitz and L. Fothergill and B. Morgan and H. Morris},
  journal={Nature},
  year={1975},
  volume={258},
  pages={577-579}
}

J. Hughes, T. Smith, +3 authors H. Morris

Published 1975

Chemistry, Medicine

Nature

View on Nature

ncbi.nlm.nih.gov

Save to Library

Create Alert

Cite

Launch Research Feed

Enkephalin, a natural ligand for opiate receptors is composed of the pentapeptides H–Tyr–Gly–Gly–Phe–Met–OH and H–Tyr–Gly–Gly–Phe–Leu–OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl–Edman procedure and by mass spectrometry followed by synthesis and comparison of the natural and synthetic peptides.