Identification of two novel nuclear import sequences on the 5-lipoxygenase protein.

@article{Jones2003IdentificationOT,
  title={Identification of two novel nuclear import sequences on the 5-lipoxygenase protein.},
  author={Sandra M. Jones and Ming Luo and Marc Peters-Golden and Thomas G. Brock},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 12},
  pages={10257-63}
}
The nuclear import of 5-lipoxygenase modulates its capacity to produce leukotrienes from arachidonic acid. However, the molecular determinants of its nuclear import are unknown. Recently, we used structural and functional criteria to identify a novel import sequence at Arg(518) on human 5-lipoxygenase (Jones, S. M., Luo, M., Healy, A. M., Peters-Golden, M., and Brock, T. G. (2002) J. Biol. Chem. 277, 38550-38556). However, this analysis also indicated that other import sequences must exist… CONTINUE READING