Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11.

@article{Yahagi2004IdentificationOT,
  title={Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11.},
  author={Shoichi Yahagi and Kazunori Shibuya and Izumi Obayashi and Hitoshi Masaki and Yoshiko Kurata and Jun Kudoh and Nobuyoshi Shimizu},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={318 3},
  pages={655-64}
}
We analyzed two novel clusters of keratin-associated protein (KAP) genes on human chromosome 11 (11p15.5 and 11q13.5) in which we identified two known human KRTAP5 genes, KerA (=KRN1) and KerB, and nine novel KRTAP5 family genes. RT-PCR analysis of these KAP genes showed preferential expression in human hair root, suggesting these gene products are required for hair formation. Based on the deduced amino acid sequences, all these KAP proteins were classified into an ultrahigh-sulfur (UHS) type… CONTINUE READING