Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus spike glycoprotein produced from the mammalian expression system.

@article{Wang2005IdentificationOT,
  title={Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus spike glycoprotein produced from the mammalian expression system.},
  author={Shixia Wang and Te-hui W. Chou and Pavlo V Sakhatskyy and S Huang and John M. Lawrence and Hong Cao and Xiaoyun Huang and Shan Lu},
  journal={Journal of virology},
  year={2005},
  volume={79 3},
  pages={1906-10}
}
The Spike (S) protein of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) plays important roles in viral pathogenesis and potentially in the development of an effective vaccine against this virulent infectious disease. In this study, the codon-optimized S gene of SARS-CoV was synthesized to construct DNA vaccine plasmids expressing either the full-length or segments of the S protein. High titer S-specific immunoglobulin G antibody responses were elicited in rabbits… CONTINUE READING

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Deglycosyla - tion of asparagine - linked glycans by peptide : N - glycosidase F

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