Identification of two human nuclear proteins that recognise the cytosine-rich strand of human telomeres in vitro.

@article{Lacroix2000IdentificationOT,
  title={Identification of two human nuclear proteins that recognise the cytosine-rich strand of human telomeres in vitro.},
  author={L. Lacroix and H Li{\'e}nard and Emmanuel Labourier and Mojgan Djavaheri-Mergny and J Lacoste and Henrik Christian Leffers and Jamal Tazi and Claude H{\'e}l{\`e}ne and Jean-Louis Mergny},
  journal={Nucleic acids research},
  year={2000},
  volume={28 7},
  pages={
          1564-75
        }
}
Most studies on the structure of DNA in telomeres have been dedicated to the double-stranded region or the guanosine-rich strand and consequently little is known about the factors that may bind to the telomere cytosine-rich (C-rich) strand. This led us to investigate whether proteins exist that can recognise C-rich sequences. We have isolated several nuclear factors from human cell extracts that specifically bind the C-rich strand of vertebrate telomeres [namely a d(CCCTAA)(n)repeat] with high… CONTINUE READING

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