Identification of two genetic markers that distinguish pathogenic and nonpathogenic strains of Acanthamoeba spp.

@article{Howe1997IdentificationOT,
  title={Identification of two genetic markers that distinguish pathogenic and nonpathogenic strains of Acanthamoeba spp.},
  author={Daniel K. Howe and Michael H. Vodkin and Robert J. Novak and Govinda Visvesvara and Gwenn McLaughlin},
  journal={Parasitology Research},
  year={1997},
  volume={83},
  pages={345-348}
}
Species-level identification of Acanthamoeba isolates is difficult and gives little or no indication of the isolate's pathogenicity. We identified two amplification-based genetic markers that were highly correlated with pathogenicity in Acanthamoeba spp. One marker, designed to amplify a 485-bp fragment of the small-subunit ribosomal RNA gene (ssrDNA), was preferentially amplified from the nonpathogenic strains; amplifications from the pathogenic strains yielded anomalous fragments of 650 and… CONTINUE READING

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