Identification of two essential glutamic acid residues in glycogen synthase.

  title={Identification of two essential glutamic acid residues in glycogen synthase.},
  author={Emili Cid and Roger R Gomis and Roberto A. Geremia and Joan J. Guinovart and Juan C. Ferrer},
  journal={The Journal of biological chemistry},
  volume={275 43},
The detailed catalytic mechanism by which glycosyltransferases catalyze the transfer of a glycosyl residue from a donor sugar to an acceptor is not known. Through the multiple alignment of all known eukaryotic glycogen synthases we have found an invariant 17-amino acid stretch enclosed within the most conserved region of the members of this family. This peptide includes an E-X(7)-E motif, which is highly conserved in four families of retaining glycosyltransferases. Site-directed mutagenesis was… CONTINUE READING
20 Citations
2 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 20 extracted citations


Publications referenced by this paper.
Showing 1-2 of 2 references

Glycosyl Transfer (Sinnott, M. L., ed) pp 119–208

  • G. Davies, M. L. Sinnott, S. G. Withers
  • 1998

Identification of Catalytic Amino Acids of Glycogen Synthase

  • E. A. Petroni, L. Ielpi
  • J. Bacteriol
  • 1996

Similar Papers

Loading similar papers…