Identification of two essential glutamic acid residues in glycogen synthase.

@article{Cid2000IdentificationOT,
  title={Identification of two essential glutamic acid residues in glycogen synthase.},
  author={Emili Cid and Roger R Gomis and Roberto A. Geremia and Joan J. Guinovart and Juan C. Ferrer},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 43},
  pages={33614-21}
}
The detailed catalytic mechanism by which glycosyltransferases catalyze the transfer of a glycosyl residue from a donor sugar to an acceptor is not known. Through the multiple alignment of all known eukaryotic glycogen synthases we have found an invariant 17-amino acid stretch enclosed within the most conserved region of the members of this family. This peptide includes an E-X(7)-E motif, which is highly conserved in four families of retaining glycosyltransferases. Site-directed mutagenesis was… CONTINUE READING
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