Identification of two different RNase H activities associated with yeast RNA polymerase A.

@article{Iborra1979IdentificationOT,
  title={Identification of two different RNase H activities associated with yeast RNA polymerase A.},
  author={François Iborra and Janine Huet and B Br{\'e}ant and A. Sentenac and Pierre Fromageot},
  journal={The Journal of biological chemistry},
  year={1979},
  volume={254 21},
  pages={10920-4}
}
Two ribonuclease H activities have been found in yeast RNA polymerase A. The nuclease activities comigrated with subunits A49 (Mr = 49,000) and A40 (Mr = 40,000), after electrophoresis in a sodium dodecyl sulfate polyacrylamide gel containing [32P](rG)n . (dC)n as substrate. Both activities were also found, among other nucleases, in a high salt chromatin extract. Several lines of evidence suggest that the chromatin RNase H of 49,000 daltons (RNase H49) is the same protein as subunit A49. They… CONTINUE READING

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