Identification of two amino acids in the hemagglutinin glycoprotein of measles virus (MV) that govern hemadsorption, HeLa cell fusion, and CD46 downregulation: phenotypic markers that differentiate vaccine and wild-type MV strains.

@article{Lecouturier1996IdentificationOT,
  title={Identification of two amino acids in the hemagglutinin glycoprotein of measles virus (MV) that govern hemadsorption, HeLa cell fusion, and CD46 downregulation: phenotypic markers that differentiate vaccine and wild-type MV strains.},
  author={V Lecouturier and J Fayolle and M B Caballero and Juan Caraba{\~n}a and Mar{\'i}a Luisa Celma and Rafael Fern{\'a}ndez-Mu{\~n}oz and T. Fabian Wild and Robin Buckland},
  journal={Journal of virology},
  year={1996},
  volume={70 7},
  pages={4200-4}
}
We have used site-directed mutagenesis of the hemagglutinin (H) glycoprotein of measles virus (MV) to investigate the molecular basis for the phenotypic differences observed between MV vaccine strains and recently isolated wild-type MV strains. The former downregulate CD46, the putative cellular receptor of MV, are positive for hemadsorption, and are fusogenic in HeLa cells, whereas the latter are negative for these phenotypic markers. CD46 downregulation in particular, could have profound… CONTINUE READING
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