Identification of two N-terminal non-alpha-helical domain motifs important in the assembly of glial fibrillary acidic protein.

@article{Ralton1994IdentificationOT,
  title={Identification of two N-terminal non-alpha-helical domain motifs important in the assembly of glial fibrillary acidic protein.},
  author={Julie E. Ralton and Xin Yuan Lu and Aileen M. Hutcheson and Roy A Quinlan},
  journal={Journal of cell science},
  year={1994},
  volume={107 ( Pt 7)},
  pages={1935-48}
}
The non-alpha-helical N-terminal domain of intermediate filament proteins plays a key role in filament assembly. Previous studies have identified a nonapeptide motif, SSYRRIFGG, in the non-alpha-helical N-terminal domain of vimentin that is required for assembly. This motif is also found in desmin, peripherin and the type IV intermediate filament proteins. GFAP is the only type III intermediate filament protein in which this motif is not readily identified. This study has identified two motifs… CONTINUE READING