Identification of two KH domain proteins in the alpha-globin mRNP stability complex.

@article{Kiledjian1995IdentificationOT,
  title={Identification of two KH domain proteins in the alpha-globin mRNP stability complex.},
  author={Megerditch Kiledjian and Xun Wang and S. A. Liebhaber},
  journal={The EMBO journal},
  year={1995},
  volume={14 17},
  pages={4357-64}
}
Accumulation of globin mRNAs during erythroid differentiation is dependent on their extraordinary stability. The longevity of human alpha-globin mRNA is associated with a ribonucleoprotein complex (alpha-complex) formed on the 3' untranslated region (3'UTR). One or more of the proteins within this alpha-complex contain strong polycytosine [poly(C)] binding (alpha PCB) activity. In the present report we purify alpha PCB activity from human erythroid K562 cells. Although not able to bind the… CONTINUE READING

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