Identification of two DNA-binding sites on the globular domain of histone H5.

@article{Goytisolo1996IdentificationOT,
  title={Identification of two DNA-binding sites on the globular domain of histone H5.},
  author={Fermı́n A. Goytisolo and Sue Ellen Gerchman and Xinzi Yu and Catherine Rees and Vito Graziano and Venkatesh Ramakrishnan and Jean O. Thomas},
  journal={The EMBO journal},
  year={1996},
  volume={15 13},
  pages={3421-9}
}
The nature of the complexes of histones H1 and H5 and their globular domains (GH1 and GH5) with DNA suggested two DNA-binding sites which are likely to be the basis of the preference of H1 and H5 for the nucleosome, compared with free DNA. More recently the X-ray and NMR structures of GH5 and GH1, respectively, have identified two basic clusters on opposite sides of the domains as candidates for these sites. Removal of the positive charge at either location by mutagenesis impairs or abolishes… CONTINUE READING

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