Identification of tumor suppressor loci on the long arm of chromosome 5 in pulmonary large cell neuroendocrine carcinoma.

@article{Shin2004IdentificationOT,
  title={Identification of tumor suppressor loci on the long arm of chromosome 5 in pulmonary large cell neuroendocrine carcinoma.},
  author={Ju Hye Shin and Shin Myung Kang and Young Sam Kim and Dong Hwan Shin and Joon Chang and Sung Kyu Kim and Se Kyu Kim},
  journal={Chest},
  year={2004},
  volume={128 4},
  pages={
          2999-3003
        }
}
BACKGROUND A recent cytogenetic analysis of non-small cell lung cancer revealed hot-spot regions for deletion on the long arm of chromosome 5 and suggested the existence of putative tumor suppressor genes in that region. However, similar studies on genetic alterations in large cell neuroendocrine carcinoma (LCNEC) have been very limited. To our knowledge, this is the first report to screen for the loss of heterozygosity (LOH) and to examine the location of putative tumor suppressor genes on… CONTINUE READING
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