Identification of transcription factor binding sites from ChIP-seq data at high resolution

@article{Bardet2013IdentificationOT,
  title={Identification of transcription factor binding sites from ChIP-seq data at high resolution},
  author={Ana{\"i}s F. Bardet and Jonas Steinmann and Sangeeta Bafna and Juergen A. Knoblich and Julia Zeitlinger and Alexander Stark},
  journal={Bioinformatics},
  year={2013},
  volume={29 21},
  pages={
          2705-13
        }
}
MOTIVATION Chromatin immunoprecipitation coupled to next-generation sequencing (ChIP-seq) is widely used to study the in vivo binding sites of transcription factors (TFs) and their regulatory targets. Recent improvements to ChIP-seq, such as increased resolution, promise deeper insights into transcriptional regulation, yet require novel computational tools to fully leverage their advantages. RESULTS To this aim, we have developed peakzilla, which can identify closely spaced TF binding sites… CONTINUE READING

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