Identification of trace-amine-associated receptors (TAAR) in the rat aorta and their role in vasoconstriction by β-phenylethylamine

@article{Fehler2010IdentificationOT,
  title={Identification of trace-amine-associated receptors (TAAR) in the rat aorta and their role in vasoconstriction by β-phenylethylamine},
  author={Martina Fehler and Kenneth J. Broadley and William R. Ford and Emma J. Kidd},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2010},
  volume={382},
  pages={385-398}
}
Trace amines including tyramine and β-phenylethylamine (β-PEA) increase blood pressure and cause vasoconstriction which is attributed to indirect sympathomimetic actions. However, there is evidence that they may also have non-sympathomimetic mechanisms. This study examined whether β-PEA causes vasoconstriction of rat aorta by a sympathomimetic action or through the recently described trace-amine-associated receptors (TAAR). Concentration–response curves (CRCs) for β-PEA were constructed either… CONTINUE READING

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Autonomic pharmacology

  • KJ Broadley
  • 1996
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