Identification of total reversible cysteine oxidation in an atherosclerosis model using a modified biotin switch assay.

@article{Li2015IdentificationOT,
  title={Identification of total reversible cysteine oxidation in an atherosclerosis model using a modified biotin switch assay.},
  author={Ru Li and Jiqing Huang and Juergen Kast},
  journal={Journal of proteome research},
  year={2015},
  volume={14 5},
  pages={2026-35}
}
Oxidative stress due to the imbalance of reactive oxygen species (ROS) and the resulting reversible cysteine oxidation (CysOX) are involved in the early proatherogenic aspect of atherosclerosis. Given that the corresponding redox signaling pathways are still unclear, a modified biotin switch assay was developed to quantify the reversible CysOX in an atherosclerosis model established by using a monocytic cell line treated with platelet releasate. The accumulation of ROS was observed in the model… CONTINUE READING
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