Identification of thrombin activatable fibrinolysis inhibitor (TAFI) in human platelets.

  title={Identification of thrombin activatable fibrinolysis inhibitor (TAFI) in human platelets.},
  author={Laurent O Mosnier and Paula Buijtenhuijs and Pauline F. Marx and Joost C M Meijers and Bonno N. Bouma},
  volume={101 12},
Thrombin activatable fibrinolysis inhibitor (TAFI) is a carboxypeptidase B-like proenzyme that after activation down-regulates fibrinolysis. Platelets are known to contain antifibrinolytic factors that are secreted during platelet activation. Therefore, the presence of TAFI in platelets was analyzed. TAFI was identified in platelets in a concentration of about 50 ng/1 x 109 platelets and was secreted on platelet activation. Thrombin-mediated activation of platelet-derived TAFI resembled that of… CONTINUE READING
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