Identification of three novel mRNA splice variants of GITR

  title={Identification of three novel mRNA splice variants of GITR},
  author={Giuseppe Nocentini and Simona Ronchetti and Andrea Bartoli and Stefania Spinicelli and Domenico Vittorio Delfino and Luigi Brunetti and Graziella Migliorati and Carlo Riccardi},
  journal={Cell Death and Differentiation},
GITR is a gene belonging to the nerve growth factor-tumor necrosis factor receptor (NGF/TNFR) family that is preferentially expressed in lymphoid tissues, is overexpressed following dexamethasone treatment or T cell receptor (TCR) stimulation and is able to modulate T cell apoptosis. Like other members of the NGF/TNFR family, GITR is composed of an intracellular domain, a transmembrane domain and an extracellular domain that is crucial for the binding with the specific ligand. In particular… Expand
GITR interacts with the pro-apoptotic protein Siva and induces apoptosis
A murine member of the tumour necrosis factor receptor superfamily, named GITR, is identified and characterised and hypothesised that murine G ITR (mGITR) could bind murine Siva (mSiva), suggesting the 30 C-terminal amino residues are necessary for mSiva binding in vivo. Expand
Cloning and characterization of GITR ligand
Functional studies reveal that soluble CD8-GITRL prevents CD4+CD25+ regulatory T-cell-mediated suppressive activities and binds GITR expressed on HEK 293 cells and triggers NF-κB activation. Expand
Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation
The role and potential therapeutic modulation of this molecule system in antitumor immunity is discussed and the implications may vary among different effector cell types, differ upon signal transduction via the receptor, the ligand, and even differ among mice and men. Expand
TISSUE DISTRIBUTION OF GITR AND GITRL GITR Is Mainly Expressed in T and Natural Killer Cells
Glucocorticoid-induced TNFR-Related (GITR) protein is a member of the tumor necrosis factor receptor superfamily that modulates acquired and natural immune response. It is expressed in several cellsExpand
Role of GITR in activation response of T lymphocytes.
Results indicate that GITR inactivation does not impair the normal development of the lymphoid organs but modulates T-cell activation and programmed cell death, and suggests that G ITR is involved in the regulation of T- cell receptor/CD3-driven T-cells activation andprogrammed cell death. Expand
GITR: a multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily
In vivo, GITR activation causes development of autoimmune diseases and restores immune responses in a persistent retroviral infection model and in a tumor model, and the G ITR‐GITRL system appears crucial in regulating immunity and warrants further study. Expand
The role of tumor necrosis factor receptor superfamily members in mammalian brain development, function and homeostasis
Examination of evidence for non-immunological roles of TNFRSF members in brain development, function and maintenance under normal physiological conditions finds several aspects of brain function during inflammation will also be described, when illuminating and relevant to the non-IMmunological role of TNSF members. Expand
Multiple mechanisms for TRAF3-mediated regulation of the T cell costimulatory receptor GITR
Tumor necrosis factor receptor (TNFR)-associated factor 3 (TRAF3) plays context-specific roles in multiple receptor-mediated signaling pathways in different cell types. Mice lacking TRAF3 in T cellsExpand
Regulation of mouse 4-1BB expression: Multiple promoter usages and a splice variant
The results reveal 4-1BB also has a negative regulation system through soluble 4- 1BB produced from a splice variant induced under activation conditions, and a splicing variant was highly induced by TCR stimulation. Expand
GITR-GITRL System, A Novel Player in Shock and Inflammation
The in vivo role of the GITR/GITRL system in inflammation and shock is summarized, explaining the mechanisms responsible for their effects, considering the interplay among the different cells of the immune system and transduction pathways activated by G ITR and GITRL triggering. Expand


LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing.
  • G. Screaton, X. Xu, +4 authors J. Bell
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1997
The expression of LARD is more tightly regulated than that of either Fas or TNF-R1 as it is found predominantly on lymphocytes but not on macrophages or a number of transformed lymphocyte cell lines. Expand
Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas.
TNF superfamily ligands show for the immune response an involvement in the induction of cytokine secretion and the upregulation of adhesion molecules, activation antigens, and costimulatory proteins, all known to amplify stimulatory and regulatory signals. Expand
A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis.
GITR is a new member of tumor necrosis factor/nerve growth factor receptor family involved in the regulation of T cell receptor-mediated cell death. Expand
An antagonist decoy receptor and a death domain-containing receptor for TRAIL.
Ectopic expression of TRID protected mammalian cells from TRAIL-induced apoptosis, which is consistent with a protective role. Expand
Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule.
Levels of soluble Fas were elevated in patients with systemic lupus erythematosus, and mice injected with soluble Fas displayed autoimmune features. Expand
Comparison of the exonic structure of GITR and its alternative splicings (exon
  • J. Biol. Chem
  • 1992