Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.

@article{Hong2014IdentificationOT,
  title={Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.},
  author={Kyung-Won Hong and Ji Eun Lim and Jong Wook Kim and Yasuharu Tabara and Hirotsugu Ueshima and Tetsuro Miki and Fumihiko Matsuda and Yoon Shin Cho and Yeonjung Kim and Bermseok Oh},
  journal={Human molecular genetics},
  year={2014},
  volume={23 24},
  pages={6659-67}
}
The electrocardiogram has several advantages in detecting cardiac arrhythmia-it is readily available, noninvasive and cost-efficient. Recent genome-wide association studies have identified single-nucleotide polymorphisms that are associated with electrocardiogram measures. We performed a genome-wide association study using Korea Association Resource data for the discovery phase (Phase 1, n = 6805) and two consecutive replication studies in Japanese populations (Phase 2, n = 2285; Phase 3, n… CONTINUE READING