Identification of three new Ig lambda-like genes in man

  title={Identification of three new Ig lambda-like genes in man},
  author={H Chang and Ethan Dmitrovsky and P. Hieter and Karen Mitchell and Philip Leder and L Turoczi and Ilan R. Kirsch and Gregory F. Hollis},
  journal={The Journal of Experimental Medicine},
  pages={425 - 435}
Three new human lambda L chain-like Ig genes are identified by restriction enzyme and nucleotide sequence analysis. Two genes, 14.1 and 16.1, have intact J and C regions, and are potentially functional, with open reading frames. A third gene, 18.1, is a pseudogene. The evolutionary lineage of these genes compared to the known functional locus lambda C1-lambda C6 can be surmised from Southern blot and nucleotide homologies. This study demonstrates that the human lambda gene family is more… CONTINUE READING