Identification of thieno[3,2-b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase.

@article{Ontoria2006IdentificationOT,
  title={Identification of thieno[3,2-b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase.},
  author={Jesus Maria Ontoria and Jose Ignacio Martin Hernando and Savina Malancona and Barbara Attenni and Ian G Stansfield and Immacolata Conte and Caterina Ercolani and J{\"o}rg Habermann and Simona Ponzi and Marcello Di Filippo and Uwe Koch and Michael Rowley and Frank Narjes},
  journal={Bioorganic & medicinal chemistry letters},
  year={2006},
  volume={16 15},
  pages={4026-30}
}
Thieno[3,2-b]pyrroles are a novel class of allosteric inhibitors of HCV NS5B RNA-dependent RNA polymerase which show potent affinity for the NS5B enzyme. Introduction of a polar substituent in the position N1 led to a compound that efficiently blocks subgenomic HCV RNA replication in HUH-7 cells with an EC50 of 2.9 microM.