Identification of the znuA-encoded periplasmic zinc transport protein of Haemophilus ducreyi.

@article{Lewis1999IdentificationOT,
  title={Identification of the znuA-encoded periplasmic zinc transport protein of Haemophilus ducreyi.},
  author={David A. Lewis and Julia Klesney-Tait and S R Lumbley and Christine K. Ward and J L Latimer and Catherine A. Ison and Eric J. Hansen},
  journal={Infection and immunity},
  year={1999},
  volume={67 10},
  pages={
          5060-8
        }
}
The znuA gene of Haemophilus ducreyi encodes a 32-kDa (mature) protein that has homology to both the ZnuA protein of Escherichia coli and the Pzp1 protein of H. influenzae; both of these latter proteins are members of a growing family of prokaryotic zinc transporters. Inactivation of the H. ducreyi 35000 znuA gene by insertional mutagenesis resulted in a mutant that grew more slowly than the wild-type parent strain in vitro unless ZnCl(2) was provided at a final concentration of 100 microM… CONTINUE READING

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