Identification of the xenosensors regulating human 5-aminolevulinate synthase.

  title={Identification of the xenosensors regulating human 5-aminolevulinate synthase.},
  author={Michael Podvinec and Christoph Handschin and Renate Looser and Urs A. Meyer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 24},
Heme is an essential component of numerous hemoproteins with functions including oxygen transport, energy metabolism, and drug biotransformation. In nonerythropoietic cells, 5-aminolevulinate synthase (ALAS1) is the rate-limiting enzyme in heme biosynthesis. Upon exposure to drugs that induce cytochromes P450 and other drug-metabolizing enzymes, ALAS1 is transcriptionally up-regulated, increasing the rate of heme biosynthesis to provide heme for cytochrome P450 hemoproteins. We used a combined… CONTINUE READING
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