Identification of the volume-sensitive organic osmolyte/anion channel in human glial cells.

@article{Jackson1997IdentificationOT,
  title={Identification of the volume-sensitive organic osmolyte/anion channel in human glial cells.},
  author={P. Suzanne Jackson and Joseph R. Madsen},
  journal={Pediatric neurosurgery},
  year={1997},
  volume={27 6},
  pages={286-91}
}
Cellular use of small organic solutes known as organic osmolytes for regulation of the volume of the cell is a universal biological phenomenon. During swelling, cells open an anion channel which allows for efflux of these solutes. This channel is known as the volume-sensitive organic osmolyte/anion channel (VSOAC). Anion channels with properties identical to VSOAC were found in human brain cells obtained following pediatric neurosurgical procedures. The tissues examined included tumors as well… CONTINUE READING