Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome

@inproceedings{Duchon2011IdentificationOT,
  title={Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome},
  author={Arnaud Duchon and Matthieu Raveau and Claire Chevalier and Val{\'e}rie Nalesso and Andrew J. Sharp and Yann H{\'e}rault},
  booktitle={Mammalian Genome},
  year={2011}
}
Down syndrome (DS) is the most frequent genetic disorder leading to intellectual disabilities and is caused by three copies of human chromosome 21. Mouse models are widely used to better understand the physiopathology in DS or to test new therapeutic approaches. The older and the most widely used mouse models are the trisomic Ts65Dn and the Ts1Cje mice. They display deficits similar to those observed in DS people, such as those in behavior and cognition or in neuronal abnormalities. The Ts65Dn… CONTINUE READING