Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain.

@article{Spiteri2007IdentificationOT,
  title={Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain.},
  author={Elizabeth J. Spiteri and Genevieve Konopka and Giovanni Coppola and Jamee M. Bomar and Michael Oldham and Jing Ou and Sonja C Vernes and Simon E. Fisher and Bing Ren and Daniel H. Geschwind},
  journal={American journal of human genetics},
  year={2007},
  volume={81 6},
  pages={1144-57}
}
Mutations in FOXP2, a member of the forkhead family of transcription factor genes, are the only known cause of developmental speech and language disorders in humans. To date, there are no known targets of human FOXP2 in the nervous system. The identification of FOXP2 targets in the developing human brain, therefore, provides a unique tool with which to explore the development of human language and speech. Here, we define FOXP2 targets in human basal ganglia (BG) and inferior frontal cortex (IFC… CONTINUE READING
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