Identification of the thiamin salvage enzyme thiazole kinase in Arabidopsis and maize.

@article{Yazdani2013IdentificationOT,
  title={Identification of the thiamin salvage enzyme thiazole kinase in Arabidopsis and maize.},
  author={Mohammad Rohollah Yazdani and R{\'e}mi G Zallot and Meral Tunc-Ozdemir and Val{\'e}rie de Cr{\'e}cy-Lagard and David K. Shintani and Andrew D. Hanson},
  journal={Phytochemistry},
  year={2013},
  volume={94},
  pages={68-73}
}
The breakdown of thiamin (vitamin B1) and its phosphates releases a thiazole moiety, 4-methyl-5-(2-hydroxyethyl)thiazole (THZ), that microorganisms and plants are able to salvage for re-use in thiamin synthesis. The salvage process starts with the ATP-dependent phosphorylation of THZ, which in bacteria is mediated by ThiM. The Arabidopsis and maize genomes encode homologs of ThiM (At3g24030 and GRMZM2G094558, respectively). Plasmid-driven expression of either plant homolog restored the ability… CONTINUE READING