Identification of the synthetic surfactant nonylphenol ethoxylate: a P-glycoprotein substrate in human urine.

@article{Charuk1998IdentificationOT,
  title={Identification of the synthetic surfactant nonylphenol ethoxylate: a P-glycoprotein substrate in human urine.},
  author={Jeffrey H M Charuk and Arthur A Grey and Reinhart A. F. Reithmeier},
  journal={American journal of physiology. Renal physiology},
  year={1998},
  volume={274 6},
  pages={F1127-F1139}
}
P-glycoprotein (Mdr1p) is an ATP-dependent drug efflux pump that is overexpressed in multidrug-resistant cells and some cancers. Mdr1p is also expressed in normal tissues like the kidney, where it can mediate transepithelial drug transport. A human urinary compound that reverses multidrug resistance and blocks [3H]azidopine photolabeling of P-glycoprotein was purified to homogeneity and identified by 1H-NMR and mass spectrometry as the synthetic surfactant nonylphenol ethoxylate (NPE… CONTINUE READING