Identification of the subunits of the nicotinic cholinergic receptors in the rat cochlea using RT-PCR and in situ hybridization.

@article{Morley1998IdentificationOT,
  title={Identification of the subunits of the nicotinic cholinergic receptors in the rat cochlea using RT-PCR and in situ hybridization.},
  author={Barbara J Morley and H. S. Li and Hakim Hiel and Dennis G. Drescher and Ana Bel{\'e}n Elgoyhen},
  journal={Brain research. Molecular brain research},
  year={1998},
  volume={53 1-2},
  pages={78-87}
}
There are two tissues in the adult mammalian cochlea that are post-synaptic to cholinergic efferent fibers: The outer hair cells (OHCs) and the dendrites of the afferent fibers of the type I spiral ganglion cells. The unusual nicotinic-like pharmacology of cochlear cholinergic responses and the unique embryonic development of cochlear tissues suggest that the inner-ear nicotinic cholinergic receptor (nAChR) may be different from nAChRs described previously at synapses in the mammalian brain… CONTINUE READING

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