Identification of the smallest structure capable of evoking opsonophagocytic antibodies against Streptococcus pneumoniae type 14.

@article{Safari2008IdentificationOT,
  title={Identification of the smallest structure capable of evoking opsonophagocytic antibodies against Streptococcus pneumoniae type 14.},
  author={Dodi Safari and Huberta A. T. Dekker and John A F Joosten and Dirk Michalik and Adriana Carvalho de Souza and Roberto Adamo and Martina Lahmann and Andreas Sundgren and Stefan Oscarson and Johannis P. Kamerling and Harm Wouter Snippe},
  journal={Infection and immunity},
  year={2008},
  volume={76 10},
  pages={4615-23}
}
Synthetic overlapping oligosaccharide fragments of Streptococcus pneumoniae serotype 14 capsular polysaccharide (Pn14PS), [6)-[beta-D-Galp-(1-->4)-]beta-D-GlcpNAc-(1-->3)-beta-D-Galp-(1-->4)-beta-D-Glcp-(1-->](n), were conjugated to CRM(197) protein and injected into mice to determine the smallest immunogenic structure. The resulting antibodies were then… CONTINUE READING