Identification of the slow reacting substances from cat paws.

  title={Identification of the slow reacting substances from cat paws.},
  author={Joel E. Houglum and Jagannath Pai and Vincent Atrache and Dae Eun Sok and Charles J . Sih},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={77 10},
Perfusion of cat paws with compound 48/80 released two slow reacting substances (SRSs) which were isolated and characterized as 5-hydroxy-6-S-cysteinylglycyl-7,9,11,14-icosatetraenoic acid (SRS I) and 5-hydroxy-6-S-cysteinyl-7,9,11,14-icosatetraeonic acid (SRS II) on the basis of chemical degradations, amino acid analyses, spectroscopic and enzymic experiments, and comparison with synthetic samples. The smooth muscle-contractile activities of synthetic 5-hydroxy-6-gamma-glutamylcysteinylglycyl… CONTINUE READING

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