Identification of the site of translational frameshifting required for production of the transposase encoded by insertion sequence IS 1

@article{Sekine1992IdentificationOT,
  title={Identification of the site of translational frameshifting required for production of the transposase encoded by insertion sequence IS 1},
  author={Yasuhiko Sekine and Hiromichi Nagasawa and Eiichi Ohtsubo},
  journal={Molecular and General Genetics MGG},
  year={1992},
  volume={235},
  pages={317-324}
}
Previous genetic analyses indicated that translational frameshifting in the −1 direction occurs within the run of six adenines in the sequence 5′-TTAAAAAACTC-3′ at nucleotide positions 305–315 in IS 1, where the two out-of-phase reading frames insA and B′-insB overlap, to produce transposase with a polypeptide segment Leu-Lys-Lys-Leu at residues 84–87. IS 1 mutants with a 1 by insertion, which encode mutant transposases with an amino acid substitution within the polypeptide segment at residues… CONTINUE READING
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