Identification of the shortest Aβ-peptide generating highly specific antibodies against the C-terminal end of amyloid-β42.

@article{Axelsen2011IdentificationOT,
  title={Identification of the shortest Aβ-peptide generating highly specific antibodies against the C-terminal end of amyloid-β42.},
  author={Trine Veje Axelsen and Arne Holm and G. Christiansen and Svend Birkelund},
  journal={Vaccine},
  year={2011},
  volume={29 17},
  pages={3260-9}
}
Alzheimer's disease (AD) is characterized by neurofibrillary tangles, consisting of hyperphosphorylated tau protein and senile plaques, which are consisting mainly of amyloid-β (Aβ). Attempts to generate a safe vaccine against Aβ rely on both B- and T-cell epitopes within the neurotoxic peptide Aβ1-42. This, however, poses a risk for an inflammatory and/or autoimmune response against Aβ-peptides in the brain. To overcome such risks we wanted to identify the shortest C-terminal Aβ-peptide that… CONTINUE READING

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