Identification of the salmon somatolactin receptor, a new member of the cytokine receptor family.

@article{Fukada2005IdentificationOT,
  title={Identification of the salmon somatolactin receptor, a new member of the cytokine receptor family.},
  author={H. Fukada and Y. Ozaki and A. Pierce and S. Adachi and K. Yamauchi and A. Hara and P. Swanson and W. Dickhoff},
  journal={Endocrinology},
  year={2005},
  volume={146 5},
  pages={
          2354-61
        }
}
Somatolactin (SL) is a pituitary hormone of the GH/prolactin (PRL) family that so far has been found only in fish. Compared with GH and PRL, the primary structure of SL is highly conserved among divergent fish species, suggesting it has an important function and a discriminating receptor that constrains structural change. However, SL functions are poorly understood, and receptors for SL have not yet been identified. During cloning of GH receptor cDNA from salmon, we found a variant with… Expand
Medaka Receptors for Somatolactin and Growth Hormone: Phylogenetic Paradox Among Fish Growth Hormone Receptors
TLDR
Interestingly, phylogenetic comparisons between the medaka SLR and growth hormone receptor (GHR), which is also isolated in this study, suggested that all GHRs reported from nonsalmonid species are, at least phylogenetically, SLRs. Expand
Subchapter 15C – Somatolactin
TLDR
Synthesis and plasma concentration of SL are also affected by sexual maturation, low environmental calcium, salinity and pH, acute stress, seasonal rhythms, background color, and plasma acidosis and bicarbonate concentration. Expand
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Production and Purification of Recombinant Somatolactin and its Effects on Insulin-like Growth Factors Gene Expression in Tilapia Hepatocytes
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Evidence is provided for the first time that SL may serve as a novel regulator in fish stimulating IGF1 and IGF gene expression in hepatocytes through its biological action in fish hepatocytes. Expand
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A novel GHR from a teleost fish (rainbow trout) is characterized and identified as a type 1 GHR (GHR1), which shares 42% and 43% amino acid identity with GHR2a and G HR2b, the two type 2 GHRs isolated from trout previously. Expand
Cloning, phylogenetic analysis and expression of somatolactin and its receptor in Cichlasoma dimerus: their role in long-term background color acclimation.
TLDR
The results suggest, for the first time, that SLR is expressed in fish scales, and that there is an increase in SL in the pituitary and the putative SLR in likely target cells, i.e., melanophores, in long-term black background exposure in C. dimerus. Expand
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TLDR
Evidence is provided that IGF can upregulate SL secretion and synthesis at the pituitary level via stimulation of MAPK- but not PI3K/Akt-dependent pathways. Expand
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Findings support the hypothesis that GHR1 is a receptor for SL, and clearly indicate tissue specific expression and differential physiological regulation of GH family receptors in the tilapia. Expand
Evolution of Receptors for Growth Hormone and Somatolactin in Fish and Land Vertebrates: Lessons from the Lungfish and Sturgeon Orthologues
TLDR
The validity of the nomenclature of the teleost-specific copy of GHR as SLR and an ancestral receptor(s) for SL before the evolution of SLR during the FSGD is discussed. Expand
Identification, synthesis and properties of a consensus peptide recognized by a monoclonal antibody directed to various type I cytokine receptors.
TLDR
The fact that polyclonal Ab to the peptide elicited in mice were able to inhibit the hGH binding to lactogenic, somatogenic and human specific liver receptors suggests that the consensus peptide could be used as an immunogen to produce anti-hGH receptor Ab behaving as hormone or cytokine antagonists in certain pathological conditions. Expand
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TLDR
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TLDR
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TLDR
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ABSTRACT The cDNA of the extracellular domain of rabbit growth hormone receptor (rbGHR-ECD) was cloned in the prokaryotic expression vector pMON, to enable its expression in Escherichia coli afterExpand
Biochemical characterization of growth hormone receptor in rainbow trout (Oncorhynchus mykiss) before and after purification
TLDR
Results suggest that the lower molecular weight observed in salmonid (41 kDa), compared to mamals, is not due to the experimental process, and the significance of GH-R size difference between salmonids and mammals is discussed. Expand
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