Identification of the resistance of a novel molecule heat shock protein 90alpha (HSP90alpha) in Microtus fortis to Schistosoma japonicum infection.

@article{Gong2010IdentificationOT,
  title={Identification of the resistance of a novel molecule heat shock protein 90alpha (HSP90alpha) in Microtus fortis to Schistosoma japonicum infection.},
  author={Qiang Gong and Gang Cheng and Zhi-qiang Qin and De-hui Xiong and Yuan-jing Yu and Qingren Zeng and Wei-xin Hu},
  journal={Acta tropica},
  year={2010},
  volume={115 3},
  pages={
          220-6
        }
}

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References

SHOWING 1-10 OF 25 REFERENCES
Immunological characteristics of natural resistance in Microtus fortis to infection with Schistosoma japonicum.
TLDR
Investigation of the immunological characteristics of natural resistance to Schistosoma japonicum infection in Microtus fortis (MF) living in the Dongting Lake area found no significant difference between WMF and BMF.
Construction of Gene Pool of Microtus fortis and Screening Resistance Associated Genes to Infection of Schistosoma japonicum
TLDR
It can be concluded that the method which may lay foundation to clone resistance associated gene and to reveal the resistance mechanism of Microtus fortis to Schistosoma japonicum infection is concluded.
Cloning, expression and protective immunity evaluation of the full-length cDNA encoding succinate dehydrogenase iron-sulfur protein of Schistosoma japonicum
TLDR
The higher degree of egg reduction rate in the test group suggested that SjSDISP vaccine may primarily play a role in anti-embryonation or anti-fecundity immunity, and suggest that it may be a novel and partially protective vaccine candidate against schistosomiasis.
[Killing effect of schistosomula of Schistosoma japonicum by tissues/organs of Microtus fortis in vitro].
  • Q. Shen, Wei-xin Hu, Bing Xu
  • Medicine, Biology
    Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University
  • 2002
TLDR
The schistosomula-killing effect of the serum of MF was stronger than that of mice, and it was the same with the tissues/organs of MF.
Schistosoma mansoni: analysis of cercarial transformation methods.
Natural antibodies in Microtus fortis react with antigens derived from four stages in the life-cycle of Schistosoma japonicum.
TLDR
The observations indicate that even uninfected M. fortis produce antibodies which react with S. japonicum, and this presumably results in the natural resistance to infection which has been reported in these rodents.
Identification of oxadiazoles as new drug leads for the control of schistosomiasis
TLDR
Treatment of schistosome-infected mice with 4-phenyl-1,2,5-oxadiazole-3-carbonitrile-2-oxide led to marked reductions in worm burdens from treatments against multiple parasite stages and egg-associated pathologies, and protective effects exceed benchmark activity criteria set by the World Health Organization for lead compound development forschistosomiasis.
Heat shock protein and innate immunity.
TLDR
This concise review summarizes the current controversy over the role of HSPs in innate immunity.
Identification of Human Asparaginyl Endopeptidase (Legumain) as an Inhibitor of Osteoclast Formation and Bone Resorption*
TLDR
The results suggest that legumain may be a physiologic local regulator of OCL activity that can negatively modulate OCL formation and activity.
...
...