Identification of the regions of porcine VCP preventing its function in Saccharomyces cerevisiae.

@article{Madeo1997IdentificationOT,
  title={Identification of the regions of porcine VCP preventing its function in Saccharomyces cerevisiae.},
  author={Frank Madeo and Jan Schlauer and Kai Uwe Fr{\"o}hlich},
  journal={Gene},
  year={1997},
  volume={204 1-2},
  pages={145-51}
}
Cdc48p is essential for homotypic endoplasmic reticular fusion in Saccharomyces cerevisiae. It is localized at the endoplasmic reticulum during most of the cell division cycle but concentrates in the nucleus at the G1/S-transition. Its mammalian homologue VCP alternates between the endoplasmic reticulum and the centrosome in dependence of the cell cycle. Though Cdc48p and porcine VCP show a high sequence conservation--almost 70% of their amino acid residues are identical the VCP gene fails to… CONTINUE READING

Similar Papers

Loading similar papers…