Identification of the receptor component of the IkappaBalpha-ubiquitin ligase.

  title={Identification of the receptor component of the IkappaBalpha-ubiquitin ligase.},
  author={Avraham Yaron and Ada Hatzubai and Matti Davis and Iris Lavon and S. Agrawal Amit and Anthony M. Manning and Jens Skorstengaard Andersen and Matthias Mann and Frank Mercurio and Yinon Ben-Neriah},
  volume={396 6711},
NF-kappaB, a ubiquitous, inducible transcription factor involved in immune, inflammatory, stress and developmental processes, is retained in a latent form in the cytoplasm of non-stimulated cells by inhibitory molecules, IkappaBs. Its activation is a paradigm for a signal-transduction cascade that integrates an inducible kinase and the ubiquitin-proteasome system to eliminate inhibitory regulators. Here we isolate the pIkappaBalpha-ubiquitin ligase (pIkappaBalpha-E3) that attaches ubiquitin, a… CONTINUE READING

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